SENTINEL Flavor Tabs may be used con currently with CAPSTAR® (nitenpyram) Tablets to provide a Flea Management System that kills adult fleas and prevents flea eggs from hatching. Concurrent use of adulticide product may be necessary for adequate control of adult fleas. Lufenuron controls flea populations by preventing the development of flea eggs and does not kill adult fleas. SENTINEL Flavor Tabs are also indicated for the prevention of heartworm disease caused by Dirofilaria immitis, for the prevention and control of flea populations, the control of adult Ancylostoma caninum (hookworm), and the removal and control of adult Toxocara canis and Toxocara leonina (roundworm) and Trichuris vulpis (whipworm) infections. SENTINEL Flavor Tabs are indicated for use in dogs and puppies, four weeks of age and older, and two pounds body weight or greater. Indications and Usage for Sentinel Flavor Tabs Lufenuron prevents most flea eggs from hatching or maturing into adults and thus prevents and controls flea populations by breaking the life cycle. After biting a lufenuron-treated dog, the female flea ingests a blood meal containing lufenuron which is subsequently deposited in her eggs. Lufenuron has no effect on the adult flea. Lufenuron’s mode of action is interference with chitin synthesis, polymerization and deposition. Lufenuron, the other active ingredient, SENTINEL Flavor Tabs, is an insect development inhibitor which breaks the flea life cycle by inhibiting egg development. Milbemycin oxime eliminates the tissue stage of heartworm larvae and the adult stage of hookworm ( Ancylostoma caninum), roundworm ( Toxocara canis and Toxascaris leonine) and whipworm ( Trichuris vulpis) infestations when administered orally according to the recommended dosage schedule. Milbemycin oxime, one active ingredient in SENTINEL Flavor Tabs, is a macrocyclic anthelmintic which is believed to act by interfering with invertebrate neurotransmission.
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